Real Madrid drawn at Zaragoza, Copa holders Valencia visit Cultural
Real Madrid and Valencia face potential banana skins in the Copa del Rey last 16, the holders facing Atletico Madrid's conquerors.
Real Madrid must again overcome lower-league opposition in the Copa del Rey last 16, while holders Valencia go to giant-killers Cultural Leonesa.
Zinedine Zidane's Madrid survived a scare against Unionistas de Salamanca in the previous round, and they will this time visit Real Zaragoza, who are fourth in LaLiga 2.
Barcelona were also tested by minnows in the previous round, scraping past Ibiza, but they have the benefit of a home fixture as they bid to reach the quarter-finals.
With LaLiga sides kept apart where possible, the Blaugrana were selected in one of just two ties solely involving top-tier teams.
They will face Leganes at Camp Nou while the majority of their LaLiga rivals are away from home.
Segunda B side Cultural defeated Atletico Madrid in extra-time on Thursday, and their reward is a meeting with Valencia, who beat Barca in last season's final.
Badajoz, the only other third-tier side remaining in the competition, also have LaLiga opposition in the form of Granada.
The second all-LaLiga tie saw Real Sociedad drawn at home to Osasuna.
Copa del Rey last-16 draw in full:
Badajoz v Granada Cultural Leonesa v Valencia Tenerife v Athletic Bilbao Real Zaragoza v Real Madrid Mirandes v Sevilla Rayo Vallecano v Villarreal Barcelona v Leganes Real Sociedad v Osasuna
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