It was just four days ago, when Manchester City went against Southampton for Carabao Cup in the same venue and today the two teams will meet for their Premier League clash in Etihad Stadium for one more time.
Hasenhüttl’s side were beaten 3-1 by Guardiola's men on Tuesday, which means they haven’t been the winner for 5 matches in a row now.
This season the Sky Blues are the Premier League's top scorers with 32 goals from their opening 10 games, while the Saints have the division's worst defense, having conceded 25 goals already. In fact, they are coming off a horrific 0-9 home loss to Leicester to face the best attackers in the country.
About the teams’ absentees, it has to be said that the Citizens will go against their rivals, missing Leroy Sane, Rodri, Oleksandr Zinchenko, and Aymeric Laporte, while reserve left-back Angelino will probably be absent as well.
On the contrary, Djenepo and Cedric are the headline names on Southampton's injured list, with Bertrand out due to suspension. In his absence, Danso is likely to start.
Looking back through history, we will see that Manchester City have won each of their last five Premier League meetings with Southampton, their longest ever winning run against Saints in league competition.
After winning their first-ever Premier League game at the Etihad in April 2004, Southampton are winless in their last eight away games against Man City, drawing one and losing seven matches.
As we mentioned Manchester City are the highest scorers in the Premier League this season, while Southampton have conceded the most in the competition so far, with the Citizens registering the biggest home win this season with the result of 8-0 and Saints suffering the biggest defeat with the result of 9-0.
Manchester City haven’t lost a home league game against a side starting the day in the relegation zone since November 2008 where they lost 1-2 against Tottenham, winning 24 and drawing three since.
Both of Southampton’s wins in the Premier League this season have been away from home. However, in their top-flight history they’ve only won two of their 42 away games against reigning champions, beating Leeds 3-1 in 1969-70 and Chelsea 3-1 in 2015-16.
Manchester City: Ederson, Walker, Otamendi, Stones, Mendy, D. Silva, Gundogan, De Bruyne, B. Silva, Aguero, Sterling.
Southamptdaon: Gunn, Valery, Stephens, Vestergaard, Bednarek, Danso, Ward-Prowse, Romeu, Hojbjerg, Ings, Redmond.
Date: Saturday, 02 November
Time: 16:00 CET
Venue: Etihad Stadium
Referee: Lee Mason