Real Madrid will be without Eden Hazard not only against Barca but also maybe for a number of other matches as the the injury to the forward's ankle seems more serious than it looked.
Eden Hazard will miss two crucial matches for Real Madrid against Manchester City and Barcelona after suffering a hairline fracture to his right ankle.
Hazard limped off in the second half of Los Blancos' 1-0 defeat to Levante on Saturday and received treatment for the injury on the bench.
It's not yet clear for how long Hazard should stay out but reports in Spain suggest another long lay-off meaning the former Chelsea star will not face Manchester City in Wednesday's Champions League last-16 first-leg tie, and Barca in a crucial Clasico in LaLiga next weekend.
A club statement read: "Following the tests carried out today [Sunday] on our player, Eden Hazard, by the Real Madrid medical department, he has been diagnosed with a fracture to his right distal fibula.
"His recovery will continue to be assessed."
Having just recovered from a fracture injury to his right ankle received in a match against Paris Saint-Germain in November last weekend, the 29-year-old forward was blown with another one in his debut campaign.
The start of Hazard's Madrid career was delayed by a hamstring problem he suffered in August and the timing of his latest setback could hardly have been worse.
Madrid's loss to Levante means they have ceded top spot in LaLiga to Barca ahead of the Clasico, while their fight for a 14th European crown restarts in a huge clash with Pep Guardiola's City.
Speaking after the game, Madrid coach Zinedine Zidane admitted the initial analysis of Hazard was not promising.
"It doesn't look good," Zidane told reporters at a news conference."It can become weak where you've had an injury. It is a blow, let's see.
"It's sore now but we'll see tomorrow when we do more tests."
Hazard has made just 15 appearances for Madrid since joining them from Chelsea last July.